The results for OS were similar; in colon cancer the five-year OS for patients without CB2 expression was 78.98% (95% CI, 69.73%-84.39%) versus 40.07% ( 95% CI, 21.8%-58.34%) for patients with CB2 expression (p < 0.001), while in rectal cancer the five-year OS was 67.88% (95% CI, 50.44%-85.32%) for patients without CB2 expression versus 44.82% ( 95% CI, 20.14%-69.5%) for patients with CB2 expression (p =0.12). This evidence concerns the gene CNR2 and rectal cancer.