FLT3 and acute myeloid leukemia: In our study, using high-throughput 8-plex iTRAQTM based proteomics approach, we have comprehensively characterized the anti-leukemic effects of genistein in AML cells using two different cell lines: one containing an inherent FLT3-ITD mutation in the FLT3 gene (MV4-11) and the other with the wild-type FLT3 gene (HL-60).