Also, in the Zhao study [47], the authors had put forth the idea that TERT is normally silenced in non-cancerous cells, but that rearrangements upstream of TERT may allow the promoter to escape the repressive chromatin environment and thereby activate telomerase expression; we examined our TCGA DNA methylation data for any evidence of this in ChRCC. Here, TERT is linked to chromophobe renal cell carcinoma.