Hypermethylation of the NBAT1 promoter and G/G genotype at the high-risk neuroblastoma-associated SNP were found to be significantly associated with lower expression of NBAT1 in high-risk patients, suggesting that both CpG methylation and G/G genotype contribute to lower expression of NBAT1 in high-risk patients. The gene discussed is NBAT1; the disease is neuroblastoma.