Since it has been demonstrated that miR-222 can target p27kip1, a critical regulator of cell cycle (49), and the phosphatase 2A subunit B (PPP2R2A), which inhibits Akt phosphorylation (48), we can assess that HMGA overexpression contributes to NSCLC progression by dysregulating cell cycle and Akt signaling (48) (Figure 1B). The gene discussed is AKT1; the disease is non-small cell lung carcinoma.