HMGA2 and adenoma: Indeed, whereas one study reported that HMGA2 is overexpressed only in 50% of colon carcinoma tissues in comparison to the average expression of normal adjacent mucosa (26), another one showed that HMGA2 expression (evaluated as percentage of stained cells) progressively increased with the severity of carcinoma grade (Dukes’ A–D), in any case, it is absent in non-neoplastic and early adenomas (27).