Further, down-regulated levels of miR-195 and miR-138 act as tumor suppressor by targeting cyclin D1 and cyclin D3 (56, 57), while onco-miRs miR-221 and miR-222 promote tumor growth by down-regulating p27, p57, and DNA damage inducible transcript 4 (58). Here, PAK2 is linked to neoplasm.