COPS5 and neoplasm: Pan et al.41 used T83 (a new 4-arylidene curcumin analogue) to inhibit the expression of Jab1 in NPC cells, demonstrating that inhibition of Jab1 could reduce tumor cell growth, induce G2/M arrest, and increase tumor cell apoptosis, thus enhancing the sensitivities of NPC cells to radiotherapy.