Interestingly, the H3K27me3 writer EZH2 was the second most highly upregulated transcript (Figure 1E, FC 331R/331 = 3.4, FC NEPC/PCa = 9.2), implying that H3K27me3 and its downstream epigenetic effects may be potentiated in the molecular context of NEPC. Here, EZH2 is linked to posterior cortical atrophy.