In confirmation of our hypothesis, we show that specific CpGs within TGFβ1 (CpG2) and PDGFα (CpG3) (Figure 1B,E) are significantly more methylated in patients with mild fibrosis whereas PPARα (CpG3) and PPARδ (CpG2) show considerably less methylation in the same group (Figure 1A,B). This evidence concerns the gene PDGFA and fibrosis.