Moreover, betatrophin levels were associated with serum irisin and FINS in women with NGT, whereas there was no correlation between betatrophin and irisin in subjects with newly diagnosed T2DM; circulating betatrophin was positively correlated with weight, BMI and hip circumference but negatively correlated with FPG and HOMA-IR. This evidence concerns the gene FNDC5 and type 2 diabetes mellitus.