However, our study found no correlation between betatrophin and irisin in women with newly diagnosed T2DM, which might be due to the following reasons: exercise involved in irisin expression and secretion was not evaluated in this study, and diabetes mellitus is a group of metabolic diseases influenced by many factors (such as obesity, blood lipids, insulin, dietary and so on), and we only excluded the confounding factor of obesity in our study. Here, FNDC5 is linked to obesity due to melanocortin 4 receptor deficiency.