Spearman’s correlation analysis revealed that serum betatrophin levels in females with NGT were positively correlated with irisin and negatively correlated with FINS (p < 0.05) (Figure 2), but no correlation was found between betatrophin and irisin in males with NGT or in males or females with T2DM (data not shown). The gene discussed is FNDC5; the disease is type 2 diabetes mellitus.