Spearman’s correlation analysis revealed that serum betatrophin levels in females with NGT were positively correlated with irisin and negatively correlated with FINS (p < 0.05) (Figure 2), but no correlation was found between betatrophin and irisin in males with NGT or in males or females with T2DM (data not shown). Here, ANGPTL8 is linked to type 2 diabetes mellitus.