CTLA4 and neoplasm: In a study using intravital microscopy in the mouse model B16/BL6, Pentcheva-Hoang et al. analyzed the motility of reporter pmel-1 T cells and reported that chronic anti-CTLA-4 treatment increased pmel-1 T-cell velocity in tumors and in tumor-draining lymph nodes, whereas acute CTLA-4 blockade increased pmel-1 T-cell velocity exclusively in tumor-draining lymph nodes (22).