The role of APOE genotype in risk for development of Alzheimer's is well known (Saunders et al., 1993; Strittmatter et al., 1993; LaDu et al., 1994; Weisgraber and Mahley, 1996), and the potential additive effect of having APOE ε4 allele(s) on the risk for developing Alzheimer's in risk-conferring neurological conditions such as in head trauma (Nicoll et al., 1995; Reinvang et al., 2013) and in temporal lobe epilepsy (Mackenzie and Miller, 1994; Gouras et al., 1997; Aboud et al., 2012, 2013) has been reported. This evidence concerns the gene APOE and temporal lobe epilepsy.