MAPT and early-onset autosomal dominant Alzheimer disease: The co-localization of dynein and βAPP as well as dynein and hyperphosphorylated tau in Alzheimer disease is consistent with the idea that—unlike the state of affairs in aged controls—spent or misfolded proteins, that would otherwise be transported back to the soma for degradation or recycling, are sequestered in aggregates in neurites and in somas.