Full gene screens of BRCA 1 and BRCA2 using a comparator method such as Sanger DNA sequencing would not have been practical due to limitations such as the time required to develop an assay for DNA extracted from FFPE tumour tissue, and the amount of DNA that would have been required to carry out complete screens of both BRCA1 and BRCA2. The gene discussed is BRCA1; the disease is neoplasm.