In this study we examined the feasibility of analysing ovarian and breast FFPE tumour tissue for significant variants (pathogenic variants, suspected pathogenic variants and variants of uncertain significance [VUS]) in BRCA1 and BRCA2 using pre-developed commercially available multiplex PCR library preparation panels for NGS, which had been designed with short amplicons to accommodate fragmented DNA from FFPE tissue. This evidence concerns the gene BRCA2 and neoplasm.