Interest in chemokines in RA has been revived by findings such as detection of citrullinated chemokines in RA synovial fluid that have enhanced chemotactic activity37 and the prospect of using antichemokine targeting for therapeutic purposes.38, 39 We have interpreted the high levels of CXCL4 and CXCL7 found in early RA compared with resolving arthritis or established RA to represent a transient upregulation of these cytokines based on a cross-sectional analysis of samples; it would be interesting to confirm the transient nature of this upregulation in a longitudinal study. The gene discussed is PPBP; the disease is arthritic joint disease.