For classification of the established RA and uninflamed groups, analysis of the obtained relevance matrix revealed that the 10 most informative genes in discriminating patients with established RA from uninflamed controls were CXCL7, CXCL4, IL1B, MST1, CCL20, IL8, LGALS12, LTA, CXCL13 and OSM (figure 2A). The gene discussed is OSM; the disease is rheumatoid arthritis.