BRCA1 and breast carcinoma: A recent meta-analysis assessing the prevalence of BRCA1 mutations in TN versus non-TN breast cancer patients from largely high-risk breast cancer populations [42] estimated a risk of 5.65 (95% CI, 4.15 to 7.69) based on analysis of 236 BRCA1 mutation carriers and 2,297 non-carriers.