Our ER-grade analysis results for BRCA1 are consistent with results from analysis of raw data for a smaller dataset of 600 BRCA1 carriers aged younger than 60 years and 258 age-matched non-carriers from the Breast Cancer Linkage Consortium, which yielded LRs of 1.94 (95% CI = 1.05 to 3.56) and 2.95 (95% CI = 2.41 to 3.62) for ER-negative grade 2 and ER-negative grade 3 tumors, respectively [26],[27]. The gene discussed is BRCA1; the disease is breast cancer.