BRCA1 and breast carcinoma: TN status has not been obviously linked to BRCA2 mutation status previously; however, a recent study of 43 deleterious BRCA1/2 mutation carriers identified from screening of 409 Chinese familial breast cancer cases reported that TN phenotype was more likely to be exhibited by both BRCA1 (P =0.001, 69%, n = 16) and BRCA2 (P =0.01, 46%, n = 27) carriers identified in their cohort, compared with non-carriers (23%; n = 366) [43].