Thus, TME at primary site increases tumor dispersion via paracrine signals by generating a chemotactic relay system, a case that can be further exemplified by CXCL14 secreted by CAFs, or EGF and CXCL5 released by tumor-associated dendritic cells in prostate and lung tumors, respectively [82,83]. The gene discussed is CXCL14; the disease is neoplasm.