Bioavailability of EGF and IGF-I increases the expression of transcription factors associated with pluripotency, proliferation, and phenotypic transition, whereas combinatorial therapy to target EGF and IGF-I signaling prevents metastatic growth, suggesting that plasticity and recurrence rates can be dictated by host systemic factors and offer remarkable therapeutic potential for triple-negative breast cancer patients. This evidence concerns the gene IGF1 and triple-negative breast carcinoma.