Resembling the stromal lineages, cancer cells can also enhance vasculature permeability, particularly at the site of extravasation where normal endothelial cells are tightly organized, to gain transendothelial entrance by secreting factors including angiopoietin 1, angiopoietin-like 4, cytochrome c oxidase subunit 2, epiregulin, matrix metalloproteinase (MMP)-1/2/3/10, TGF-β, and VEGF in the case of lung or brain carcinoma [31]. This evidence concerns the gene TGFB1 and cancer.