CASP2 and cancer: Cell death by apoptosis depends on the cascade-like activation of proteases of the Caspase family.1 Among these, the evolutionarily most conserved protease, Caspase-2, turns out to be a potent tumor suppressor in mice2, 3, 4, 5, 6, 7 and correlative expression data support a conserved role in human cancer.8, 9, 10, 11, 12, 13