Hence, it remains possible that the phenomenon of reduced p53 activation in the absence of Caspase-2 is cell type-specific, for example, in lung epithelium,40 and/or a particular secondary hit, or a fully transformed cellular state.37 Consistent with the latter scenario, we previously reported on a reduced selective pressure to inactivate p53 in Eμ-Myc lymphomas lacking Caspase-2.4 Here, MYC is linked to lymphoma.