As it is difficult to connect these observations with known substrates of Caspase-2 and the analysis of representative p53-induced genes failed to support impaired murine double minute 2 activity, as reported in cisplatin-treated lung cancer cells,40 we performed whole transcriptome analysis on premalignant Eμ-Myc pre-B cells lacking or expressing Caspase-2 (or Raidd). Here, CASP2 is linked to lung cancer.