Trastuzumab and pertuzumab have significantly improved outcomes for patients with HER-2 amplified breast cancer [1], while the EGFR-directed antibody cetuximab improves response and survival in patients with head and neck cancer [2-4] and cetuximab and the EGFR-directed antibody panitumumab prolong survival in selected patients with colorectal cancer [5,6]. The gene discussed is EGFR; the disease is head and neck cancer.