Currently, the main biomarkers applied for CIN detection are proteins related to the cell cycle, such as p16INK4A, Ki-67, minichromosome maintenance 7 and 2 (MCM7 and 2), topoisomarase II alpha, and cyclin D1, all of which have altered expression due to the effects of HPV on the cell cycle. The gene discussed is CDKN2A; the disease is cervical squamous intraepithelial neoplasia.