We observed a strong nuclear staining for RAP1 in CIN 2/3 samples, as previously reported in oropharyngeal SCC cell lines and human oral cancer specimens, and for other small GTPases, such as RHO and RAC1, in premalignant lesions and cervical cancer [6,7,12,29]. This evidence concerns the gene RHO and cervical squamous intraepithelial neoplasia.