RAP1 seems to play a role in cancer cell growth, invasion, and metastasis, and dysregulation of RAP1 activation has been described in several malignant cell lines and cancers, such as oropharyngeal squamous cell carcinoma (SCC), papillary thyroid cancer, breast cancer, renal cell carcinoma, and melanoma [12–18]. This evidence concerns the gene RAP1A and hereditary clear cell renal cell carcinoma.