In the EuroSIDA cohort in which most participants were taking ART and who had a nadir CD4+ cell count of 178 cells, non-AIDS events that included malignancies, major CVD events, pancreatitis, major liver disease events and end-stage renal disease were associated with latest CD4+ cell count but the association was weaker than the association of latest CD4+ count and AIDS [14]. The gene discussed is CD4; the disease is chronic kidney disease.