IRS2 and cancer: miR-98 has also been shown to target molecules that have been associated with different forms of cancer, such as HMGA2, which exerts a transforming effect on lung cancer cells [35], IRS2, a protein that is up-regulated in colorectal cancer that leads to an increase in wnt signaling [36] and IGF2BP which has been documented to promote hepatocellular carcinoma [37].