NFKB1 and carcinoma: Importantly, we observed a deregulation of NF-κB signalling pathway in our set of human CC samples, with increased NF-κB steady-state levels in human colon adenomas (P<0.001), stage B–D pMMR carcinomas (stage B and C, P<0.01; stage D, P<0.05) and dMMR carcinomas (P<0.01), compared with normal colon mucosa (Figure 1c, left panel, and 1f).