MAP2K5 and cancer: The relevance of MEK5/ERK5 signalling in cancer is increasing exponentially due to its demonstrated pro-survival, pro-proliferative and pro-angiogenic roles.5, 6, 7 Further, aberrant expression of MEK5/ERK5 was already reported in several human cancers.8, 9, 10, 11, 14, 22, 23 Our results now demonstrate the overexpression of MEK5 and ERK5 in human colon adenomas and adenocarcinomas.