In addition, ERK5 expression and NF-κB activation are also significantly further increased in tumours with more than four regional lymph nodes involved (N2) and in cases with distant metastasis at presentation (M1), compared with tumours with less aggressive phenotypes (P<0.05 versus N0–1 and M0, respectively; Table 1). The gene discussed is NFKB1; the disease is neoplasm.