MAPK7 and colon adenoma: In addition, ERK5 steady-state levels were also significantly increased in human colon adenomas (P<0.001), in stage B–D pMMR carcinomas (stage B, P<0.01; stage C, P<0.01; stage D, P<0.05) and also in dMMR carcinomas (P<0.05), compared with normal colonic mucosa (Figures 1a and b, right panel, and Figure 1f).