A clear understanding of how individual sirtuins function in different cancer types is important for assessing their potential as therapeutic targets.34 The involvement of sirtuins in tumorigenesis has promoted research into the effect of sirtuin inhibitors on different cancer cell lines.35 However, a recent study by Finley et al.14 shows that SIRT3 functions as a tumor suppressor, and loss of SIRT3 promotes tumorigenesis by altering global cellular metabolism. This evidence concerns the gene SIRT3 and cancer.