P300/CBP-associated factor (PCAF) is a member of the GNAT (GCN5-related N-acetyltransferase) acetyltransferase family which was originally found to repress cellular transformation as a factor displaced from p300/CBP complexes by oncoprotein E1A.5 Recent studies have demonstrated that PCAF modulates the activities of several oncogenes and tumour repressors through acetylation of either histones or transcription factors, consequently impacting cancer progression. Here, KAT2B is linked to cancer.