The critical roles of PCAF in cell apoptosis, synergistic antitumor effects of PCAF and 5-FU, and the significant correlation of PCAF with postsurgical survival of HCCs strongly suggest that PCAF may have utility as a predictor of outcome of HCCs after surgery and also that 5-FU treatment may have a better therapeutic effect in HCC patients with high tumor PCAF expression. This evidence concerns the gene KAT2B and neoplasm.