The main strengths of our study are the assessment of clinical phenotypes (myocardial infarction, cardiovascular and all-cause mortality) in three prospective cohorts of type 1 and type 2 diabetes and the genotyping of tagSNPs covering the haplotype block containing SOD3. We also investigated associations of the clinical phenotypes and SOD3 genotypes with three markers of redox status. The gene discussed is SOD3; the disease is myocardial infarction.