This mechanism was seen in our work and has been seen by others, including in persistent hyperinsulinemic hypoglycemia of infancy caused by mutant pancreatic ATP-sensitive potassium SUR1/Kir6.2 channels [45] and in long QT type 2 syndrome caused by Kv11.1 channel mutations [46]. The gene discussed is KCNJ11; the disease is hyperinsulinemic hypoglycemia.