HLA-C and melanoma: To further investigate the clinical relevance of the 17 T-cell specificities detected after MHC multimer-based enrichment of PBMCs, we screened TIL cultures generated from 30 melanoma patients (18 HLA-A1+, 16 HLA-A3+, 4 HLA-A11+, 3 HLA-B7+ and 27 with unknown HLA-B7 status) for the presence of T-cell populations, recognizing any of these or three virus-derived peptides (HLA-A1/CMV pp50VTE, HLA-A3/CMV pp150VTT and HLA-B7/CMV pp65RPH).