In view of the observation that the expression intensity of NCRs was found to be increased on NK cells after IL-15 activation, and a role for NKp30 and NKp46 has been reported in killing of neuroblastoma cell lines [19], each of the NCRs, i.e., NKp30, NKp44 and NKp46, alone or in combination with DNAM-1 and NKG2D receptors, was blocked during the cytotoxicity assays. The gene discussed is CD226; the disease is neuroblastoma.