Although the risk of developing secondary diabetes for patients with negative PR expression (HR = 0.530; 95 % CI 0.372–0.755 (P < 0.001)) was higher than for those with positive PR expression, the risk of developing secondary diabetes for patients with negative ER expression was slightly higher than for those with positive ER expression (HR = 0.806; 95 % CI 0.566–1.146 (P = 0.230)), which was not statistically significant. This evidence concerns the gene ESR1 and diabetes mellitus.