In this sense, and also considering the existence in the literature of controversial results in sHLA-G levels and severity in different autoimmune diseases (such as in Systemic Lupus Erythematosus [41, 42]), it would be important not only to access the presence and levels of sHLA-G in autoimmune patients but also to perform tests evaluating the its recognition by its cognate receptors. The gene discussed is HLA-G; the disease is systemic lupus erythematosus.