MNTX had the same effect on the pancreatic cancer cell line PANC-1 (Doc: 71.3 ± 8.1%, Doc/MNTX: 51.3 ± 4.2%, Fig 3E), and pancreatic cancers often express OGF and are well known to show diffuse growth (S1 Fig). The gene discussed is PENK; the disease is familial pancreatic carcinoma.