KRAS and cancer: A comparison has been made of the in vitro G4 stabilizing properties with anti-proliferative activity of the IQc compounds with high (2d, 3d, 3e) and low (1, 2a) G4 ΔTm values, against a panel of KRAS-dependent (lung, pancreas and colon) and independent (breast) cancer cell lines and non-malignant cell lines (lung fibroblasts).