To characterize the expression of IFNβ and a representative IFN-inducible gene (Isg56) in CNS autoimmunity over a long term period we immunized C57BL/6 N mice with MOG35–55 peptide (hereafter referred to as MOG) and characterized gene expression for 70 days. The gene discussed is IFNB1; the disease is Autoimmunity.