CCR8 and colorectal carcinoma: We also analyzed the expression of CCR8 and its ligand CCL1 using RNA sequencing data from the TCGA cohort as well as using unpublished quantitative real-time PCR data from our previous study [35] comprising 125 samples and show that CCR8, and to lesser extent CCL1, are expressed in human CRC tissue (Figure S10 in Additional file 1).