Protein levels including Akt, Erk1/2, Stat5 (Figure 5C) and the p65 subunit of NF-κB proteins (Figure 5D) were significantly decreased in the GA-treated tumors, while proteasome target protein IκB-α and the ubiquitinated proteins were highly accumulated in GA-treated tumors versus the control (Figure 5D), indicating that GA inhibits proteasome function in both GCB- and ABC-DLBCL xenografts. Here, MAPK3 is linked to diffuse large B-cell lymphoma.