When analyzing the expression of MITF-M in two melanoma cell lines, LB2201-MEL and LB2259-MEL, we observed a significant downregulation of the expression of MITF-M mRNA after incubation with IL-1ß for 4h and 24h, consistent with a previous study from our laboratory (Fig 1A) [19]. This evidence concerns the gene IL1A and melanoma.