Using reporter constructs containing 4.5kb and 15kb promoter fragments encompassing the MITF-M transcriptional start site and binding sites for known regulators of MITF-M (e.g. PAX3 and SOX10, [29] [30] [31]), we did not observe any effect of IL-1ß on reporter gene activity in the melanoma cell line LB2259-MEL (data not shown). This evidence concerns the gene PAX3 and melanoma.