Despite being rare, TARDBP mutation screening should be considered even in FTD cases without signs or symptoms of MND, especially when other more frequent cause of genetic FTD (i.e. GRN, C9ORF72, MAPT) have been excluded and when family history is complex comprising parkinsonism, motor neuron disease and frontotemporal dementia. This evidence concerns the gene TARDBP and motor neuron disorder.