TARDBP and amyotrophic lateral sclerosis: The 43-kDa transactive response (TAR)-DNA-binding protein (TARDBP; MIM# 605078) was identified in 2006 as the primary constituent of the ubiquitin-positive and tau-negative neuronal and glial inclusions found in brains of patients with frontotemporal lobar degeneration (FTLD-TDP) and ALS, suggesting a common pathogenesis in these disorders [3-5].