TARDBP and proteostasis deficiencies: Altogether, the co-occurrence of different proteinopathies in our cases (TDP-43, ß-amyloid and 4-repeat tau) and that described by Gelpi et al. [28] (TDP-43, tau and alpha-synuclein) points to a pathogenic mechanism that facilitates misfolded protein interaction and aggregation or a loss of TDP-43 function that somehow impairs protein clearance.