On selected disorders, we measured EBNA2 overlap and found no significant enrichment inside obesity and UC susceptibility loci (O/E for obesity = 0.4565-fold, p = 0.8378; O/E for UC = 1.892-fold, p = 0.06522); on the contrary, RA and SLE regions showed results comparable to those seen in MS (O/E for RA, MHC included = 4.776-fold, p = 9.99e-05; O/E for SLE, MHC included = 6.4-fold, p = 9.99e-05) (Table 3); analyses performed without considering MHC regions yielded similar results (data not shown). Here, HLA-C is linked to obesity due to melanocortin 4 receptor deficiency.