Muscular dystrophies arising from sarcolemmal defects, like Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophy (2C, 2D, and 2E), where the DGC is detached from the sarcolemma, show loss of nNOS from the sarcolemma [29–31]. The gene discussed is NOS1; the disease is Duchenne muscular dystrophy.