MYC and post-transplant lymphoproliferative disease: The molecular pathogenesis of PTLD caused by EBV infection may involve genetic or epigenetic alterations of several cellular genes, such as translocations (involving C-MYC, IGH, BCL-2, BCL-6), various copy number variations, DNA mutations (PIM1, PAX5, p53, C-MYC, RhoH/TTF), DNA hypermethylation, and polymorphisms in both the host cell's genome (IFN-gamma, IL-10, TGF-beta, HLA) and the EBV genome (Capello and Gaidano, 2009).