Comparison of MAFs from liver metastasis of CRC with skin fibroblasts revealed up-regulation of genes of adhesion molecules, ECM/ECM remodeling molecules, proteases/protease inhibitors, and several growth factors and survival cytokines, including PDGFA, FGF-1, IGFBP-7, IGFBP-5, CTGF, prostate differentiation factor, VEGF, TGF-β2, monocyte chemotactic protein-1 (MCP-1), IL-6, osteoprotegerin, follistatin, follistatin-related gene, COX-2, and TGF-β (20). Here, IL6 is linked to colorectal carcinoma.