Erlotinib (Tarceva®, Roche, Basel, Switzerland; 1, Figure 1) is a first-generation reversible 4-anilinoquinazoline inhibitor of EGFR and was approved in 2004 for NSCLC treatment of patients with locally advanced or metastatic NSCLC in combination with chemotherapy. This evidence concerns the gene EGFR and non-small cell lung carcinoma.