ERBB2 and breast cancer: In a previous study, we reported the production of 64Cu-labeled trastuzumab, specifically 64Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-trastuzumab and that 64Cu-DOTA-trastuzumab PET imaging could detect primary HER2-positive breast cancer and metastatic lesions [10].