Recently, an analysis of renal allograft biopsies from kidney transplant patients isolated one year post-transplantation found that the majority of infiltrating macrophages were CD68+ CD204+ tissue remodeling/fibrotic (M2) macrophages characterized by increased expression of IFN-γ-responsive genes and that macrophage infiltration strongly correlated with the subsequent development of renal fibrosis [261]. Here, CD68 is linked to renal fibrosis.