An analysis of the response of human monocyte-derived DC isolated from SSc patients found an altered response to TLR stimulation in DC from patients with either the limited or diffuse form of SSc compared to those of normal patients with increased expression of IL6 and IFN-α and decreased expression of IL-12 whereas IL-10 expression was markedly increased only in SSc patients with diffuse disease [215]. This evidence concerns the gene IL6 and systemic sclerosis.