The role of CAV1 in cardiac interstitial fibrosis was examined in experimentally induced myocardial infarction in mice and reported that deletion of CAV1 resulted in increased numbers of tissue remodeling/fibrotic (M2) macrophages in the infarct zone and that infusion of the CAV1 scaffolding domain peptide abrogated the increased tissue remodeling/fibrotic (M2) macrophage accumulation and reduced cardiac fibrosis [266]. Here, CAV1 is linked to Interstitial cardiac fibrosis.