ITGAX and renal fibrosis: In a mouse model of UUO-induced renal fibrosis, the numbers of both Cd11c+ F4/80+ and Cd11c+ F4/80- increased 24 hours after injury with both subpopulations displaying increased MCH2 and CD68 positivity, however Cd11c- DTR-specific depletion either at 1 day pre-UUO or 5 days post-UUO had no effect on levels of type III collagen, α-SMA, TGF-β or TNF-α [262].