For instance, it has recently been reported that overexpression of Dyrk1a, a member of the tyrosine-phosphorylation-regulated protein kinase family located at chromosome 21 [56], reduces the magnitude of physiological apoptosis in the developing retina of trisomic Ts65Dn mice, leading to a phenotype that resembles that seen in DS individuals [57]. Here, DYRK1A is linked to Dravet syndrome.