Direct evidence for tissue specific function of Lamin proteins comes from mutations in the human Lamin A (LMNA) gene, which lead to an array of serious diseases called laminopathies, including cardiomyopathy, muscular dystrophy, lipodystropy, neuropathy and progeria (Dittmer and Misteli, 2011). The gene discussed is LMNA; the disease is cardiomyopathy.