HMW adiponectin is decreased in obesity and type II diabetes and increased in type I diabetes (Yang et al., 2001; Pajvani and Scherer, 2003; Yatagai et al., 2003; Flier, 2004; Wolf et al., 2004; Pereira et al., 2012). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.