CD37 and leukemia: Figure 2 displays the signaling pathway implicated by the mechanistic studies of Lapalombella et al., which explains why several anti-CD37 therapeutics drive apoptosis in leukemia cells (Zhao et al., 2007; Heider et al., 2011; Krause et al., 2012; Lapalombella et al., 2012; Deckert et al., 2013; Beckwith et al., 2014).