It is well documented that Smad3 is pathogenic since knockout of Smad3 gene inhibits fibrosis in obstructive nephropathy (Sato et al., 2003), diabetic nephropathy (Fujimoto et al., 2003), hypertensive nephropathy (Liu et al., 2012), and drug-toxicity-related nephropathy (Zhou et al., 2010). The gene discussed is SMAD3; the disease is hypertensive nephropathy.