Chylomicron-retention disease (CMRD) due to mutations in the SAR1B gene, encoding for Sar1b, is an example of failure in the transport of prechylomicrons through the secretory pathway even though the ER assembly process takes place correctly (Cefalù et al., 2010; Shoulders et al., 2014). This evidence concerns the gene SAR1B and chylomicron retention disease.